A New Class of TherapiesBased on a New Understanding of How the Immune System Works

Modulation of the gut-body network has therapeutic potential in major disease areas.

We are developing a new class of medicines that are designed to act on immune cells in the gut for effects throughout the body.

More about Evelo

The gut-body network and monoclonal microbials

  • The gut is central to human biology and is connected to all parts of the body via the lymphatic system.
  • Microbes have naturally evolved to modulate systemic biology through the gut-body network.

Based on these two central principles of previously underappreciated biology, we are developing a new class of medicines – monoclonal microbials.

Our Portfolio

We are advancing multiple monoclonal microbial product candidates into clinical studies across oncology and inflammatory diseases. We dosed the first subject in our clinical trial of our first monoclonal microbial product candidate in our inflammation portfolio, EDP1066. First-in-human studies of our additional lead product candidates are expected to begin in 2018 and to deliver 10 clinical readouts across inflammatory diseases and cancer throughout 2019 and 2020.

About our portfolio

Evelo is led by a team with deep experience.

Our leadership team has founded, led and grown transformative platform biotechnology companies. Our team has also developed and commercialized medicines that have impacted many lives.

About our team

Founder and Investors

Evelo was founded by Flagship Pioneering. Flagship VentureLabs’ innovators conceived of and developed Evelo’s foundational inventions, leading to the launch of Evelo Biosciences in 2015. Additional investors in Evelo include GV (the venture capital arm of Alphabet, Inc.), Celgene, the DDF (Dementia Discovery Fund), Fidelity, Mayo Clinic and Alexandria Real Estate Equities.

Investors page

The destination for pioneers and adventurers

If you want to join an exceptional team and culture that is committed to driving profound benefits to patients and society, let us know.

Careers page


620 Memorial Drive | Suite 200 West | Cambridge, MA, 02139 USA

For general inquiries contact:

For media inquiries contact:

For investor inquiries contact: